All joint compounds with the exception of Megaloc will not be removed easily. You should check with the materials manufacture that you are removing the pipe joint compound from first, to confirm what cleaning chemicals are compatible with their product. Start by trying to remove the pipe joint compound with white vinegar and working your way up to acetone. Remember to always test a small out of sight area first, before damaging the finishes or affecting the integrity of materials that the pipe joint compound was adhered to. Megaloc can however be cleaned off hands and tools with a dry rag, and easily washes out of cloths with soap and water.